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Target intelligence / Profile preview
hERG potassium channel (hERG)
- Target
- hERG
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
The hERG potassium channel (KCNH2) is a voltage-gated potassium channel essential for cardiac repolarization and maintaining normal heart rhythm. It is also expressed in nerve cells and microglia within the central nervous system. Mutations or pharmacological inhibition can cause long QT syndrome, leading to arrhythmias and sudden cardiac death. Many drugs inadvertently block this channel, making it a key anti-target during drug development.
- Other names
- KCNH2Kv11.1ERGERG1human Ether-à-go-go-Related Gene
02
Mechanism of action
hERG channel blockade leading to QT interval prolongation
03
Biological functions
Cardiac myocyte repolarizationRegulation of heart rateNeuron excitabilityMicroglia function
04
Disease associations
Long QT syndrome (LQTS)Short QT syndromeArrhythmiasSudden cardiac deathCancer
05
Safety considerations
Drug-induced QT prolongationTorsade de pointesCardiotoxicity
06
Biomarkers
hERG expression in cancer cells
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