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Target intelligence / Profile preview
Herpes Simplex Virus DNA Polymerase (HSV DNA polymerase)
- Target
- HSV DNA polymerase
- Molecular classification
- Enzyme, DNA polymerase, Viral protein
01
Overview
Herpes simplex virus (HSV) DNA polymerase is a key enzyme required for the replication of the viral genome during productive infection of HSV-1 and HSV-2. It is encoded by the UL30 gene and forms a holoenzyme with the UL42 processivity factor. The enzyme possesses DNA polymerase, 3'-5' exonuclease (proofreading), and ribonuclease H activities. It is the primary target for antiviral drugs like acyclovir, but resistance can develop through mutations in UL30 or viral kinases.
- Other names
- UL30Pol/UL30HSV-1 DNA polymeraseHSV-2 DNA polymerase
02
Mechanism of action
Inhibition of viral DNA polymerase activity, leading to chain termination during DNA synthesis.
03
Biological functions
Viral genome replicationDNA synthesisProofreading (3'-5' exonuclease activity)Ribonuclease H activity
04
Disease associations
InfectionHerpes simplex virus infectionViral disease
05
Safety considerations
Drug resistanceNephrotoxicity (with some nucleoside analogues)
06
Interacting drugs
Acyclovir
3 more in the full profile.
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