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Target intelligence / Profile preview
Herpes Simplex Virus Entry Process (HSV Entry Process)
- Target
- HSV Entry Process
- Molecular classification
- Viral infection, Cellular entry pathway
01
Overview
The herpes simplex virus (HSV) entry process is a complex, multi-step mechanism involving coordinated interactions between viral glycoproteins and specific host cell surface receptors. This process enables the virus to attach, penetrate, and deliver its genetic material into the host cell for replication. Key steps include attachment, receptor engagement, membrane fusion or endocytosis, capsid transport, and genome release. Viral glycoproteins gB, gC, gD, and gH/gL, along with host cell receptors like heparan sulfate proteoglycans, Nectin-1/-2, and HVEM, are crucial for this process. The virus exploits calcium signaling pathways and microtubule-based transport. Entry variations exist depending on target cell type. After nuclear delivery of DNA, subsequent steps include genome replication and assembly within infected cells before new virions are released.
- Other names
- HSV infection processHerpesvirus entry mechanism
02
Mechanism of action
N/A
03
Biological functions
Viral attachmentMembrane fusionCapsid transportGenome releaseViral replication
04
Disease associations
InfectionHerpes simplex virus infection
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