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Target intelligence / Profile preview
Herpes Simplex Virus Envelope Glycoprotein D (gD)
- Target
- gD
- Molecular classification
- Viral glycoprotein, Envelope protein
01
Overview
Herpes simplex virus envelope glycoprotein D (gD) is an essential structural component of the herpes simplex virus (HSV) envelope. It mediates viral entry into host cells by binding to specific cellular receptors (Nectin-1, HVEM, Nectin-2, and modified heparan sulfate), thereby triggering the fusion of the viral envelope with host cell membranes. It is indispensable for HSV infectivity and a key target for antiviral drug development and vaccine design. The ectodomain undergoes conformational changes upon receptor engagement, initiating downstream events for membrane fusion. The cytoplasmic domain is involved in replication, envelopment, and spread.
- Other names
- Envelope glycoprotein DHSV gDUS6 protein
02
Mechanism of action
Targeting gD prevents viral entry into host cells by blocking receptor binding and subsequent membrane fusion.
03
Biological functions
Viral entryMembrane fusionReceptor bindingVirion assemblyCell-to-cell spread
04
Disease associations
InfectionHerpes simplex virus infection
05
Safety considerations
Development of resistancePotential for off-target effects on host cell receptorsNeed for strain-specific targeting due to receptor usage variability
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