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Target intelligence / Profile preview
Herpes Simplex Virus Glycoprotein B (gB)
- Target
- gB
- Molecular classification
- Viral envelope glycoprotein, Class III fusion protein
01
Overview
Herpes simplex virus glycoprotein B (gB) is an essential viral envelope protein that mediates the fusion of the viral envelope with host cell membranes during viral entry. It is a highly conserved protein found in all herpesviruses and plays a critical role in infectivity and pathogenesis. gB acts as the primary fusogen, undergoing large conformational changes to drive membrane merger. It functions as part of a core fusion machinery along with glycoproteins gD, gH, and gL. Neutralizing antibodies targeting gB are crucial for vaccine design and therapeutic antibody development.
02
Mechanism of action
Inhibition of viral entry by preventing membrane fusion
03
Biological functions
Membrane fusionViral entryReceptor binding
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects if targeting host cell membrane fusion processes
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