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Herpes Simplex Virus Helicase-Primase Complex (HSV Helicase-Primase)
- Target
- HSV Helicase-Primase
- Molecular classification
- Enzyme, Helicase, Primase, Protein Complex
01
Overview
The herpes simplex virus (HSV) helicase-primase complex is a multi-protein enzyme essential for viral DNA replication. It is a key component of the HSV replisome, responsible for unwinding double-stranded DNA and synthesizing RNA primers necessary for DNA synthesis during viral genome replication. The complex consists of three subunits: UL5 (helicase), UL52 (primase), and UL8 (accessory). It is a target for antiviral drug development.
- Other names
- HSV UL5-UL52-UL8 ComplexHSV Helicase-PrimaseUL5-UL52-UL8 ComplexHSV DNA Replication Complex
02
Mechanism of action
Inhibition of helicase and primase activity, blocking DNA unwinding and primer synthesis, thereby halting viral replication.
03
Biological functions
DNA replicationDNA unwindingRNA primer synthesisViral genome duplication
04
Disease associations
InfectionHerpes Simplex Virus Infections
05
Safety considerations
Potential for resistance mutations (e.g., in UL5)Off-target effects on host cell DNA replication (less likely due to viral specificity)
06
Interacting drugs
Pritelivir
1 more in the full profile.
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