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Target intelligence / Profile preview
Herpes Simplex Virus Type 1 Genome (HSV-1 Genome)
- Target
- HSV-1 Genome
- Molecular classification
- Viral Genome, DNA Virus
01
Overview
The Herpes simplex virus type 1 (HSV-1) genome is a linear, double-stranded DNA molecule approximately 152,000 base pairs (bp) in length. It consists of two unique regions (UL and US) each flanked by inverted repeats. The genome encodes about 75 proteins and forms multiple isomeric forms due to recombination. During latency, the genome circularizes, and only a few RNAs are transcribed. It encodes determinants for drug resistance, virulence factors, and is a target for antiviral therapies including gene-editing approaches.
- Other names
- HSV1 GenomeHerpes Simplex Virus 1 GenomeHSV-1 DNA
02
Mechanism of action
Inhibition of viral DNA polymerase or other essential viral enzymes, disruption of viral genome function
03
Biological functions
Viral ReplicationViral TranscriptionVirion AssemblyLatency EstablishmentImmune Evasion
04
Disease associations
Orolabial HerpesGenital HerpesKeratitisEncephalitisInfection
05
Safety considerations
Drug resistanceViral reactivationPotential for off-target effects with gene editing therapies
06
Interacting drugs
Acyclovir
4 more in the full profile.
07
Biomarkers
Viral loadDetection of HSV-1 DNA in clinical samples
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