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Target intelligence / Profile preview
Herpes Simplex Virus Type 1-Infected Tumor Cell Lysis (HSV-1-Infected Tumor Cell Lysis)
- Target
- HSV-1-Infected Tumor Cell Lysis
- Molecular classification
- Viral Infection, Cell Lysis, Immunotherapy
01
Overview
Herpes simplex virus type 1 (HSV-1)-infected tumor cell lysis is the process by which HSV-1, particularly engineered or oncolytic strains, infects and destroys cancer cells. This involves direct oncolysis through viral replication within tumor cells and subsequent cell death, as well as immune activation via the release of tumor antigens and stimulation of both innate and adaptive immune responses. Engineered oncolytic HSV-1 vectors are designed for selective replication in malignant cells, often through the use of tumor-specific promoters or modifications that reduce neurovirulence while preserving oncolytic activity.
- Other names
- Oncolytic HSV-1 TherapyHSV-1 VirotherapyHerpes Simplex Virus Type 1 Oncolysis
02
Mechanism of action
Direct tumor cell lysis and immune stimulation
03
Biological functions
Tumor cell deathAntigen releaseImmune activationViral replication
04
Disease associations
Cancer
05
Safety considerations
NeurovirulenceOff-target effectsImmune response modulation
06
Interacting drugs
Anti-HSV drugs (e.g., Acyclovir)
07
Biomarkers
MHC Class I expressionTumor-associated antigens (TAAs)Telomerase activity (hTERT)
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