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Target intelligence / Profile preview
Herpes Simplex Virus Type 2 Virion (HSV-2 Virion)
- Target
- HSV-2 Virion
- Molecular classification
- Virus, Viral particle
01
Overview
The Herpes Simplex Virus Type 2 (HSV-2) virion is a complex, enveloped viral particle responsible for causing genital herpes and other infections. Its structure comprises a dsDNA genome enclosed within an icosahedral capsid, surrounded by a tegument layer containing various regulatory proteins, and an outer envelope studded with viral glycoproteins essential for cell entry. The virion's architecture facilitates protection of the genetic material, cell invasion, and immune modulation.
- Other names
- HSV2 VirionHerpes simplex virus 2 virionHSV-2 particle
02
Mechanism of action
Antiviral drugs typically target viral DNA polymerase, inhibiting viral DNA replication. Some drugs may interfere with viral entry or other stages of the viral life cycle.
03
Biological functions
Viral replicationInfectionImmune evasionCell entry
04
Disease associations
Genital herpesNeonatal herpesHerpes simplex encephalitis (rare)Other HSV-2 related infections
05
Safety considerations
Drug resistanceNephrotoxicity (foscarnet, cidofovir)Neurotoxicity (acyclovir, in rare cases)
06
Interacting drugs
Acyclovir
5 more in the full profile.
07
Biomarkers
HSV-2 DNA detection (PCR)HSV-2 antibody detection (serology)Viral load
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