Herpes Simplex Virus Uncoating Process (HSV Uncoating)

The uncoating process of the herpes simplex virus (HSV) is a critical step in viral infection, involving the release of the viral genome from its protective capsid shell into the host cell nucleus. This process is essential for initiating viral gene expression and replication. It includes capsid transport to the nucleus, docking at nuclear pore complexes, and pressure-driven ejection of viral DNA into the nucleoplasm. Viral proteins like UL6 and UL25, along with host factors like importin β and Ran-GTP, play key roles. Targeting this process could block infection before gene expression begins, presenting a potential antiviral strategy.

Other names

HSV-1 UncoatingHerpesvirus UncoatingViral Genome ReleaseCapsid Disassembly

Inhibition of viral genome release by blocking capsid docking to the nuclear pore complex or interfering with conformational changes required for DNA ejection.