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Herpesvirus DNA Polymerase
- Molecular classification
- Enzyme, DNA polymerase, B family DNA polymerase
01
Overview
Herpesvirus DNA polymerase is a key viral enzyme essential for the replication of herpesvirus genomes. It is a primary target for antiviral drugs used to treat infections caused by human herpesviruses, including herpes simplex virus (HSV) and human cytomegalovirus (HCMV). The enzyme catalyzes viral DNA synthesis, possesses proofreading activity, and functions within a holoenzyme complex. It is inhibited by nucleoside analogs and non-nucleoside inhibitors. Drug resistance can develop through mutations in the polymerase gene. Herpesvirus DNA polymerase remains one of the most validated antiviral targets, and ongoing research aims to develop new classes of inhibitors that overcome resistance mechanisms.
02
Mechanism of action
Inhibition of viral DNA synthesis via chain termination or allosteric inhibition.
03
Biological functions
DNA replicationDNA polymerizationProofreading (3'-5' exonuclease activity)Ribonuclease H activity
04
Disease associations
InfectionViral infectionHerpes simplex virus (HSV) infectionHuman cytomegalovirus (HCMV) infection
05
Safety considerations
Drug resistanceSelection of resistant virus strainsMutations in viral polymerase gene
06
Interacting drugs
Acyclovir
3 more in the full profile.
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