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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 14 (HVEM)
- Target
- HVEM
- Molecular classification
- Receptor, Tumor necrosis factor receptor superfamily, Type I transmembrane protein
01
Overview
Tumor Necrosis Factor Receptor Superfamily Member 14 (TNFRSF14/HVEM/CD270) is a type I transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It plays a crucial role in immune regulation by modulating both stimulatory and inhibitory immune responses. It acts as a co-stimulatory molecule for T cell activation via interaction with LIGHT; and can also inhibit immune responses through interactions with BTLA or CD160. HVEM is also involved in mucosal immunity and serves as an entry mediator for herpes simplex virus. Mutations or dysregulation are associated with lymphomas and autoimmune diseases.
- Other names
- TNFRSF14CD270Herpesvirus Entry MediatorATAR
02
Mechanism of action
Modulation of T cell activation and inhibition through interaction with ligands like LIGHT, BTLA, and CD160.
03
Biological functions
Immune regulationCo-stimulation of T cell activationT cell inhibitionApoptosisMucosal defenseViral entry
04
Disease associations
LymphomasAutoimmune diseasesInfectionDiffuse large B-cell lymphomaPediatric-type follicular lymphoma
05
Safety considerations
Dysregulation can lead to autoimmune diseases.Modulating HVEM may affect viral entry and immune responses, potentially leading to unintended consequences.
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