Herpesvirus entry mediator receptor (HVEM)

Herpesvirus entry mediator (HVEM; TNFRSF14; CD270) is a type I transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It serves as a crucial immune regulatory receptor, binding ligands such as LIGHT (TNFSF14), lymphotoxin-beta, and viral envelope proteins (herpesvirus glycoprotein D). HVEM mediates signal transduction that promotes T and B cell activation, enhances cytokine production, and regulates apoptosis and immune defense in both normal and disease contexts. HVEM’s interactions establish a critical checkpoint for lymphocyte proliferation, tissue architecture, and host defense, and dysregulation of this pathway has been implicated in a range of inflammatory, infectious, and malignant conditions. Targeting HVEM or its ligands is being pursued for disease intervention, but care must be exercised due to its wide-ranging roles in immune function

Other names

Herpesvirus entry mediatorTNFRSF14CD270LIGHT receptor

Antagonism of LIGHT binding (e.g., neutralizing antibodies to block LIGHT-HVEM interaction); Modulation of NF-κB signaling downstream of receptor activation