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Target intelligence / Profile preview
Herpesvirus Family DNA Polymerase (HV DNA Polymerase)
- Target
- HV DNA Polymerase
- Molecular classification
- Enzyme, DNA Polymerase, B-family DNA Polymerase
01
Overview
Herpesvirus family DNA polymerases are essential enzymes encoded by all herpesviruses. They play a central role in viral genome replication during the lytic phase of infection and are critical for viral propagation and pathogenesis. These enzymes are major targets for antiviral drugs, but long-term use can lead to drug resistance.
- Other names
- HSV DNA PolymeraseHCMV DNA PolymeraseVZV DNA PolymeraseViral DNA Polymerase (Herpesvirus)Herpesviridae DNA Polymerase
02
Mechanism of action
Chain termination after incorporation (nucleoside analogs); Direct inhibition of pyrophosphate binding (pyrophosphate analogs); Block dNTP association (non-nucleoside inhibitors)
03
Biological functions
Viral genome replicationDNA synthesisProofreadingRNA-DNA hybrid processing
04
Disease associations
InfectionViral DiseasesHerpes simplex virus infectionsCytomegalovirus infectionsVaricella-zoster virus infections
05
Safety considerations
Drug resistanceMutations in viral polymeraseMutations in viral kinase
06
Interacting drugs
Acyclovir
3 more in the full profile.
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