Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
HERV-H LTR-associating 2 (HHLA2)
- Target
- HHLA2
- Molecular classification
- B7 family of immune regulatory ligands, Immune checkpoint molecule
01
Overview
HHLA2 is a member of the B7 family of immune checkpoint molecules that regulates cell-mediated immunity. It inhibits T cell proliferation and cytokine production by binding to an unidentified receptor on T cells and antigen-presenting cells. HHLA2 is overexpressed in various cancers, promoting tumor growth and metastasis, and is associated with worse prognosis. It represents a promising target for cancer immunotherapy. It is expressed only in humans.
02
Mechanism of action
Inhibition of T cell activation and cytokine production through interaction with an unidentified receptor on T cells and antigen-presenting cells.
03
Biological functions
Inhibits T cell proliferationReduces cytokine production by T cellsRegulation of cell-mediated immunityImmune response
04
Disease associations
CancerAutoimmune diseasesInfectionTransplant rejection
05
Safety considerations
Potential for immune-related adverse events due to modulation of T cell responses.Lack of mouse ortholog complicates preclinical modeling.
06
Biomarkers
HHLA2 expression levels in tumor tissue
Beyond the preview
Go deeper on HERV-H LTR-associating 2 (HHLA2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HERV-H LTR-associating 2 (HHLA2).