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Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1)
- Target
- hnRNP A1
- Molecular classification
- RNA-binding protein, Heterogeneous nuclear ribonucleoprotein
01
Overview
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a highly conserved and ubiquitously expressed RNA-binding protein. It plays central roles in RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport, translation regulation, microRNA processing, telomere maintenance, and modulation of transcription factor activity. Dysregulation or mutation of hnRNP A1 has been implicated in neurodegenerative diseases and various cancers. It can also promote or inhibit viral replication depending on the virus.
- Other names
- HNRNPA1hnRNP A1-AhnRNP A1-B
02
Mechanism of action
N/A
03
Biological functions
Pre-mRNA processingSplicing regulationmRNA transportmRNA stabilityTranscription regulationTranslation regulationMicroRNA biogenesisTelomere maintenance
04
Disease associations
Amyotrophic lateral sclerosis (ALS)Frontotemporal lobar degeneration (FTLD)Multiple sclerosis (MS)Spinal muscular atrophy (SMA)Alzheimer's diseaseHuntington's diseaseCancerViral infection
05
Safety considerations
Aberrant aggregationStress granule formationMislocalization leading to impaired RNA metabolism
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