Heterogeneous nuclear ribonucleoprotein A1 pseudogene 21 (HNRNPA1P21)

Heterogeneous nuclear ribonucleoprotein A1 pseudogene 21 (HNRNPA1P21) is a pseudogene and not a protein-coding gene; pseudogenes are non-functional copies or variants of known genes that arise through gene duplication or retrotransposition events. The functional HNRNPA1 gene encodes an RNA-binding protein involved in the regulation of alternative splicing, RNA metabolism, and nucleocytoplasmic transport, and is implicated in diseases such as cancer and neurological disorders[1][2][3][4]. However, pseudogenes like HNRNPA1P21 do not produce functional protein products and are generally not considered therapeutic or pharmacological targets, nor do they have established roles in disease, drug interactions, or use as biomarkers. Additional context: - The confusion arises because HNRNPA1P21 is closely related in name and sequence to HNRNPA1, which is a well-studied, functional gene[3]. - There are many HNRNPA1-related pseudogenes scattered throughout the human genome[3]. - Only the functional HNRNPA1 protein is considered a drug target and associated with disease mechanisms; its pseudogenes, including HNRNPA1P21, are not[3][4]. - HNRNPA1P21 has commonly used aliases (such as HNRNPA1P) and is catalogued in gene databases as a pseudogene. Summary of errors: - HNRNPA1P21 is frequently mistaken for its parent gene, HNRNPA1, which is a legitimate protein-coding gene and therapeutic target. The pseudogene does not act as a drug target, biomarker, or disease-associated functional gene[3][4]. For structured data purposes: - Do not treat HNRNPA1P21 as a functional target or therapeutic entity. - Flag queries that use HNRNPA1P21 as ‘incorrect’ in the context of molecular pharmacology or target identification.

Other names

HNRNPA1PHNRNPA1P21