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Heterogeneous nuclear ribonucleoprotein F (HNRNPF)
- Target
- HNRNPF
- Molecular classification
- RNA-binding protein, Heterogeneous nuclear ribonucleoprotein (hnRNP) family
01
Overview
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) is a ubiquitously expressed RNA-binding protein that complexes with heterogeneous nuclear RNA (hnRNA) and regulates alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport in the nucleus. It binds primarily to guanosine-rich RNA tracts and can influence RNA maturation and export. HNRNPF is structurally characterized by three quasi-RNA recognition motif (qRRM) domains and is a member of the hnRNP protein superfamily. By modulating pre-mRNA processing and mRNA stability, HNRNPF has been implicated in the regulation of gene expression and the etiology of several disease states, including certain cancers, neurodevelopmental syndromes, and neurological disorders. It is not currently considered a direct therapeutic target for small molecule drugs or biologics.
- Other names
- hnRNP FHNRPFNucleolin-like protein mcs94-1mcs94-1OK/SW-cl.23heterogeneous nuclear ribonucleoprotein FHnRNP F protein
02
Biological functions
Regulation of alternative splicingRegulation of polyadenylation (3' end processing)Regulation of mRNA export and transportModulation of mRNA stabilityBinding to guanine-rich RNA sequences (including G-quadruplex-forming RNA)
03
Disease associations
Cancer (Ewing sarcoma, mantle cell lymphoma)Neurodevelopmental disordersDisorders related to altered splicingAddictive behavior and neuronal disorders
04
Safety considerations
Potential off-target effects if targeted, due to involvement in multiple essential RNA processing eventsBroad expression and essential functions may cause toxicity if systemically inhibited
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