Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1)

Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) is a nuclear RNA-binding protein belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family[1][2][3][5]. It binds specifically to the adenovirus E1B-55kDa oncoprotein and is thought to play vital roles in nucleocytoplasmic RNA transport, RNA processing, transcriptional regulation, DNA double-strand break repair, and modulation of gene expression. It also participates in ATR protein kinase signaling pathways, especially during adenovirus infection[3]. HNRNPUL1 can act as a basic transcriptional regulator, repressing or activating transcription depending on its interacting partners, such as BRD7[1][4]. HNRNPUL1 is not currently considered a direct therapeutic target, although it has significant disease associations. Mutations and aberrations in HNRNPUL1 or its fusions (such as MEF2D-HNRNPUL1) are implicated in leukemogenesis, notably B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and its mutations have been observed at notable frequency in cancers like uterine corpus endometrial carcinoma and stomach adenocarcinoma[2]. There are currently no drugs approved or known to interact directly with HNRNPUL1, nor is it used as a biomarker or associated with direct safety concerns in therapeutics[2][5]. Key protein-protein interactions include BRD7 and PRMT2, and its function may be modulated in viral and oncogenic contexts[1][3].

Other names

HNRNPUL1E1BAP5E1B-AP5HNRPUL1FLJ12944Adenovirus early region 1B-associated protein 5E1B-55 kDa-associated protein 5

Not applicable (no approved drugs directly target HNRNPUL1 as of current data)