Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2)

Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) is a nuclear RNA-binding protein that participates in alternative mRNA splicing, associates with chromatin, and plays a regulatory role in DNA damage repair through modulation of topoisomerase II activity[1][3][6][7]. It is localized mainly in the nucleoplasm and is dynamically associated with chromatin depending on cellular conditions[3][5][6]. HNRNPUL2 interacts with regulators of DNA topology and is rapidly recruited to the nucleus and regions of DNA damage, where its expression correlates with resistance to DNA double-strand breakage and enhanced DNA repair capacity[1]. Although closely related proteins in the hnRNP family are implicated in neurodevelopmental and other disorders, there are no current drug therapies targeting HNRNPUL2, nor is it recognized as a therapeutic receptor, enzyme, or transporter[3][6][7]. Its precise function extends to the maintenance of genomic stability, and its biological roles likely interface at the crossroads of RNA processing and DNA integrity maintenance[1].

Other names

HNRPUL2SAF-A2DKFZp762N1910Scaffold-attachment factor A2MANP (Mlf1-associated nuclear protein)hnRNPUL2heterogeneous nuclear ribonucleoprotein U-like protein 2