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Target intelligence / Profile preview
Hexokinase 2 (HK2)
- Target
- HK2
- Molecular classification
- Enzyme, Kinase
01
Overview
Hexokinase 2 (HK2) is an enzyme that catalyzes the first step of glycolysis, the phosphorylation of glucose to glucose-6-phosphate. It plays a critical role in cellular energy metabolism and is often overexpressed in cancer cells, contributing to the Warburg effect. HK2's localization to the outer mitochondrial membrane (OMM) via binding to VDAC provides a link between glycolysis and oxidative phosphorylation and confers anti-apoptotic properties. Targeting HK2 is explored as a potential anti-cancer strategy.
02
Mechanism of action
Inhibition of HK2 activity, Disruption of HK2-VDAC interaction
03
Biological functions
Glucose phosphorylationGlycolysisApoptosis regulationMitochondrial bindingEnergy metabolism
04
Disease associations
CancerMetabolic disease
05
Safety considerations
Potential for systemic metabolic disruption if HK2 inhibition is not tumor-selective
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