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Hexokinase Type II (HK2)
- Target
- HK2
- Molecular classification
- Enzyme, Kinase
01
Overview
Hexokinase type II (HK2) is an enzyme that catalyzes the first committed step in glycolysis: the phosphorylation of glucose to glucose-6-phosphate. It is the predominant hexokinase isoform in skeletal muscle and plays a crucial role in cellular energy metabolism. HK2 is overexpressed in many cancers, contributing to the Warburg effect. It also has non-metabolic functions, including modulation of transcriptional networks. HK2 localizes primarily to the outer mitochondrial membrane. Expression of HK2 is regulated by insulin, hypoxia, and other factors.
- Other names
- Hexokinase B
02
Mechanism of action
Inhibition of hexokinase activity.
03
Biological functions
Glycolysis initiationGlucose metabolismATP synthesisMitochondrial bindingRegulation of transcriptional networks
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Potential for off-target effects due to homology with other hexokinase isoformsInhibition may disrupt normal glucose metabolism
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