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Hexosamine Biosynthesis Pathway (HBP)
- Target
- HBP
- Molecular classification
- Metabolic Pathway
01
Overview
The hexosamine biosynthesis pathway (HBP) is a metabolic route that integrates glucose, glutamine, acetyl-CoA, and uridine triphosphate (UTP) to produce uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). UDP-GlcNAc is an essential metabolite used for both N-linked and O-linked glycosylation of proteins—a process critical for modulating protein activity, stability, localization, and expression. Altered HBP flux has been implicated in various diseases including diabetes, cardiovascular disease, and cancer.
- Other names
- Hexosamine Pathway
02
Mechanism of action
Inhibition of GFAT, modulation of O-GlcNAcylation
03
Biological functions
Protein glycosylation (N/O)Metabolic sensingStress responseCell cycle regulationTranscriptional control
04
Disease associations
DiabetesCardiovascular diseaseCancerInsulin resistance
05
Safety considerations
Altered glucose metabolismPotential for broad effects on glycosylation
06
Biomarkers
UDP-GlcNAc levelsO-GlcNAc modified proteins
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