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HID1 domain-containing protein (HID1)
- Target
- HID1
- Molecular classification
- Other (peripheral membrane protein)
01
Overview
HID1 domain-containing protein (HID1) is a highly conserved peripheral membrane protein associated with the medial and trans-Golgi apparatus. It is required for secretory granule maturation and is implicated in cellular processes such as insulin processing and vacuole fusion. While HID1 is proposed to participate in intracellular trafficking, its exact function and structural domains are poorly characterized, and it does not belong to any major drug target class such as receptor, enzyme, or transporter. HID1 mutations are associated with developmental and epileptic encephalopathy 105 with hypopituitarism. There is some evidence for down-regulation of HID1 in multiple cancers, but it is not a validated therapeutic target and there are currently no drugs known to interact with it[1][2][4].
- Other names
- HID1C17orf28HID-1Down-regulated in multiple cancers 1protein HID1protein hid-1 homologDEE105DMC1
02
Biological functions
Secretory granule maturationIntracellular trafficking (within the Golgi apparatus)Insulin processingVacuole fusion (non-autophagic)
03
Disease associations
Developmental and epileptic encephalopathy (DEE105)Possible broad role in cancer (down-regulated in multiple cancers, but evidence is limited)
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