HIF1A antisense RNA 3 (HIF1A-AS3)

HIF1A antisense RNA 3 (HIF1A-AS3) is a long non-coding RNA (lncRNA) transcribed from the 3′ region of the HIF1A locus. It does not encode a protein but is a regulatory RNA that modulates the expression and activity of HIF1A mRNA and HIF-1α protein, a master regulator of cellular responses to hypoxia. HIF1A-AS3 positively regulates HIF1A expression in some cell types and is required for optimal HIF-1α-mediated transcription and glycolytic responses, especially under low oxygen or high glucose conditions. Functionally, it acts partly through interactions with protein partners such as PKM2 (pyruvate kinase M2) and PHD3 (prolyl hydroxylase 3), facilitating their association and nuclear translocation, which enhances HIF-1α transcriptional programs. HIF1A-AS3 expression is upregulated under hypoxia and in certain cancers, correlating with aggressive phenotypes and worse patient outcomes. Experimental knockdown of HIF1A-AS3 reduces HIF1A mRNA and protein expression, and disrupts hypoxia signaling, making it a candidate therapeutic target for nucleic acid-based approaches in cancer and other hypoxia-associated pathologies

Other names

HIFALHIF-1alpha anti-sense lncRNAHIF1A-AS3

For experimental drugs/therapies in research: Antisense or RNA interference-mediated knockdown reduces HIF1A-AS3, decreasing HIF1A mRNA and protein and downstream HIF-1α-mediated transcription