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HIGD1AP6 (HIG1 hypoxia inducible domain family member 1A pseudogene 6) is a processed pseudogene with the Ensembl identifier ENSG00000253229[3]. It belongs to the HIG1 (hypoxia inducible domain) family and is classified as an approved pseudogene by the HUGO Gene Nomenclature Committee[2]. As a processed pseudogene, it lacks the typical intron-exon structure of functional genes and was likely formed through retrotransposition of an mRNA transcript back into the genome[4]. While traditionally considered "junk DNA," recent research suggests that some pseudogenes, including processed pseudogenes, may have regulatory functions through various mechanisms including acting as microRNA decoys, producing small interfering RNAs, or competing for regulatory factors with their parent genes[4]. However, specific functional data for HIGD1AP6 is not available in the current literature. The gene has been assigned NCBI Gene ID 100874436[5][6].
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