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Target intelligence / Profile preview
High-affinity choline transporter 1 (CHT1)
- Target
- CHT1
- Molecular classification
- Transporter, Sodium/glucose cotransporter family (SLC5)
01
Overview
The high-affinity choline transporter (CHT1), encoded by the SLC5A7 gene, is a critical membrane protein responsible for the sodium- and chloride-dependent uptake of choline into presynaptic nerve terminals. This process is essential for the synthesis of acetylcholine (ACh), a key neurotransmitter in both the central and peripheral nervous systems. CHT1 activity is rate-limiting in cholinergic signaling, ensuring efficient reutilization of choline derived from synaptic ACh breakdown, maintaining neurotransmitter supply during sustained neuronal activity. Dysfunction or genetic mutations affecting SLC5A7/CHT can impair cognitive functions due to reduced cholinergic tone.
- Other names
- CHTSLC5A7
02
Mechanism of action
Inhibition of choline transport
03
Biological functions
Choline transportAcetylcholine synthesisNeurotransmitter reuptakeRegulation of cholinergic neurotransmission
04
Disease associations
Neurodegenerative diseaseCognitive impairment
05
Interacting drugs
Hemicholinium-3
2 more in the full profile.
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