High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha (FcεRIα)

The high affinity immunoglobulin epsilon receptor subunit alpha (FcεRIα) is the alpha subunit of the high-affinity IgE receptor complex, which plays a central role in allergic responses and immunity to parasites. This protein is a type I transmembrane glycoprotein and serves as the primary binding site for immunoglobulin E (IgE). Upon binding to IgE and subsequent cross-linking by antigen/allergen, it triggers cell activation, leading to degranulation and release of mediators such as histamine, which are responsible for allergy symptoms. It also induces secretion of important lymphokines involved in immune regulation.

Other names

FCERIAFCE1AFcεRIαHigh-affinity immunoglobulin epsilon receptor subunit alpha

Target of anti-allergy drugs that aim to prevent IgE binding or downstream signaling.