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Target intelligence / Profile preview
Tropomyosin-related receptor kinase A (TrkA)
- Target
- TrkA
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK)
01
Overview
Tropomyosin-related receptor kinase A (TrkA) is a membrane-bound RTK crucially involved in nervous system development through its interaction with nerve growth factor. Its activity regulates key processes such as neuronal differentiation/survival and pain perception while genetic alterations are linked to neurological disorders and certain cancers driven by *NTRK* gene fusions or mutations.
- Other names
- TRKAhigh affinity nerve growth factor receptorneurotrophic tyrosine kinase receptor type 1TRK1-transforming tyrosine kinase protein
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Neuronal differentiationNeuronal survivalNeural proliferationNociceptor response (pain perception)Prevention of programmed cell death (apoptosis)Signal transduction
04
Disease associations
Congenital insensitivity to pain with anhidrosisSelf-mutilating behaviorsIntellectual disability/cognitive impairmentCancer
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