Target intelligence / Profile preview

High-Density Lipoprotein (None)

Target: None
Molecular classification: Lipoprotein complex

Overview

High-density lipoproteins are multifunctional complexes essential for lipid homeostasis. Their ability to remove excess cellular fats—alongside their anti-inflammatory properties—makes them central targets both diagnostically as biomarkers ("good" vs "bad" cholesterol balance) and therapeutically in efforts aimed at reducing cardiovascular morbidity/mortality.

Other names: HDLGood Cholesterol

Mechanism of action

Enhancement of reverse cholesterol transport and reduction of atherosclerosis.

Biological functions

Reverse cholesterol transportAntioxidant activityAnti-inflammatory activityLipid homeostasisInnate immunity

Disease associations

Cardiovascular disease

Safety considerations

Extremely high levels may not always be beneficial, especially in certain populations.Clinical trials have yet to conclusively prove that simply increasing measured HDL-C improves patient outcomes beyond current standard-of-care treatments.

Interacting drugs

Statins (indirectly, by affecting lipid profiles)

2 more in the full profile.

Biomarkers

HDL-C (High-density lipoprotein cholesterol)

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