High mobility group AT-hook 1 pseudogene 2 (HMGA1P2)

High mobility group AT-hook 1 pseudogene 2 (HMGA1P2, also known as HMGIYL2) is a processed pseudogene located on chromosome 4q13.3 and found only in the human genome[3]. Unlike protein-coding genes, pseudogenes like HMGA1P2 typically do not encode functional proteins; however, preliminary data suggest that HMGA1P2 can be transcribed and possibly translated into protein, potentially acting as a competitor to the HMGA1 wild-type protein[3]. HMGA1P2 can also act as a regulatory RNA, affecting the stability and expression of the functional HMGA1 gene by decoying shared miRNAs or competing for RNA-binding factors[3][4]. This regulatory interplay may impact pathways relevant to oncogenesis and metabolic regulation, though HMGA1P2 itself is not established as a direct therapeutic target, receptor, or enzyme[3]. There is currently no evidence for direct drug interactions with HMGA1P2, and its use as a clinical biomarker or therapeutic target is not documented.

Other names

HMGIYL2