High mobility group box 1 pseudogene 21 (HMGB1P21)

High mobility group box 1 pseudogene 21 (HMGB1P21) is a processed pseudogene derived from the parental gene high mobility group box 1 (HMGB1). Pseudogenes are DNA sequences similar to functional genes but typically lack coding or regulatory ability due to mutations or truncations[1][5]. While some pseudogenes may produce RNA transcripts with limited regulatory potential, there is no evidence that HMGB1P21 is functional or specifically involved in any known biological process or disease. It is not classified as a receptor, enzyme, transporter, transcription factor, or any canonical drug target. Other HMGB1 pseudogenes are sometimes reported to act as competitive endogenous RNAs influencing gene expression, but HMGB1P21 does not have published evidence of such activity[2][5]. Biogps and GeneCards list HMGB1P21 only as a pseudogene, with no confirmed biological function or disease role[1][5]. HMGB1P21 is a processed pseudogene, not a canonical molecular target. There is no evidence that it is a therapeutic or biological target. Entries regarding its target status are likely incorrect for drug targeting purposes[1][5].

Other names

high mobility group box 1 pseudogene 21HMGB1P21