High mobility group box 1 pseudogene 28 (HMGB1P28)

High mobility group box 1 pseudogene 28 (HMGB1P28) is classified as a processed pseudogene in the human genome, meaning it is derived from a duplication or retrotransposition event involving the functional HMGB1 gene but harbors mutations preventing coding of a functional protein[1][4][5]. Pseudogenes like HMGB1P28 generally do not produce proteins and have historically been regarded as nonfunctional. However, some pseudogenes are now recognized for potential regulatory functions, such as acting as RNA decoys for microRNAs or influencing the expression of their parental genes, though no specific regulatory or pathological roles have been defined for HMGB1P28[3][4][6]. The HMGB1 gene (the parent gene) encodes a protein involved in DNA binding and regulation of transcription, and is well studied in cancer and inflammation, but the HMGB1P28 pseudogene itself is not functionally active[3]. The "28" indicates it is one of many pseudogene variants related to the high mobility group box family. There are no known clinical or therapeutic applications, no documented protein expression, and no interacting drugs for HMGB1P28[1]. The entry is incorrect as a drug target due to its classification as an inactive pseudogene[1][4][5].