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Target intelligence / Profile preview
High mobility group box 1 pseudogene 31 (HMGB1P31)
- Target
- HMGB1P31
- Molecular classification
- Pseudogene, Other
01
Overview
High mobility group box 1 pseudogene 31 (HMGB1P31) is classified as a pseudogene, meaning it is a segment of DNA resembling the functional HMGB1 gene but lacking protein-coding ability or established biological function[1]. It exists within the human genome and is annotated in genomic databases, but there is no evidence to support its role as a therapeutic target, nor is it known to produce a functional RNA or protein product. Unlike its parent gene HMGB1, which encodes a well-characterized DNA-binding protein involved in chromatin remodeling and inflammatory responses, HMGB1P31 does not have confirmed biological activity. While recent research shows some pseudogenes can play regulatory or disease-related roles, such as acting as long non-coding RNAs or being differentially expressed in certain cancers, there are no such data for HMGB1P31 specifically[1][3][4][5].
- Other names
- HMGB1P31 [GeneCards ID: GC00U931273]NCBI Gene: 100873894Ensembl: ENSG00000233266
02
Biological functions
None clearly established; pseudogenes may sometimes act in gene regulation, but no experimental function is described for HMGB1P31
03
Disease associations
None specific to this pseudogene; pseudogenes in general have been found differentially expressed in cancer and development, but there is no evidence for HMGB1P31 in disease
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