High mobility group box 1 pseudogene 37 (HMGB1P37)

High mobility group box 1 pseudogene 37 (HMGB1P37) is annotated as a human pseudogene—a non-protein-coding genomic sequence related by homology to the functional High mobility group box 1 gene (HMGB1). While some pseudogenes in the human genome regulate their parent genes through non-coding RNA mechanisms, there is currently no published data indicating that HMGB1P37 has any biological activity or disease association. It is best described as a non-functional vestige or genomic relic[2]. Most databases (HGNC, GeneCards) list HMGB1P37 purely as a pseudogene, with no druggability, signaling, or biomarker attributes[2]. The scientific accuracy of using HMGB1P37 as a therapeutic target is not supported; therefore, this name should not be included in structured lists of actionable drug targets.