High mobility group box 1 pseudogene 38 (HMGB1P38)

High mobility group box 1 pseudogene 38 (HMGB1P38) is annotated as a pseudogene in the human genome and is a non-protein coding segment related in sequence to the parental high mobility group box 1 (HMGB1) gene[2][4]. Unlike canonical HMGB1, which encodes a chromatin-associated protein involved in transcriptional regulation and inflammation, HMGB1P38 does not produce a functional protein product and is not known to act as a receptor, enzyme, or therapeutic target[2][4]. There is no evidence associating HMGB1P38 directly with biological functions, disease mechanisms, or therapeutic modulation, and it does not appear in disease or signaling pathway annotations as an active participant[2][4]. Some pseudogenes in general can exert regulatory effects via RNA-based mechanisms (e.g., acting as miRNA sponges or ceRNAs), but there is no published evidence to suggest such a role for HMGB1P38 specifically[1][2]. Due to its status as a pseudogene and lack of validation as a drug or biomarker target, this entry likely reflects incorrect or irrelevant target selection in a therapeutic context.

Other names

high mobility group box 1 pseudogene 38HMGB1P38