High mobility group box 1 pseudogene 49 (HMGB1P49)

High mobility group box 1 pseudogene 49 (HMGB1P49) is classified as a pseudogene, meaning it is a non-functional copy or fragment of the HMGB1 gene without ability to encode a functional protein[2]. Pseudogenes like HMGB1P49 may sometimes have regulatory RNA functions, but there are no data or publications indicating that HMGB1P49 has any such roles or is involved in disease processes[4]. Therefore, it is not considered a therapeutic target and has no direct biological, disease, or pharmacological relevance. Note: If your interest is in the *functional* protein "High-mobility group box 1" (HMGB1), this is a non-histone chromatin-associated protein with roles in DNA binding, chromatin remodeling, and extracellular signaling in inflammation and cancer[1][3][5]. However, HMGB1P49 itself does **not** have these properties.

Other names

HMGB1P49High-mobility group box 1 pseudogene 49High-mobility group box 2 pseudogene

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