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Target intelligence / Profile preview
High mobility group box 1 pseudogene 5 (HMGB1P5)
- Target
- HMGB1P5
- Molecular classification
- Pseudogene, Non-coding RNA
01
Overview
High mobility group box 1 pseudogene 5 (HMGB1P5) is a non-coding RNA classified as a pseudogene that shares high sequence similarity with the active high mobility group box 1 (HMGB1) gene. HMGB1P5 does not encode a protein and instead may exert biological effects by acting as a competitive endogenous RNA (ceRNA), sequestering microRNAs away from HMGB1 and potentially other genes with shared microRNA response elements[4]. This can indirectly modulate the regulation of HMGB1 and may influence disease processes, including some cancers and neurodegenerative diseases, through such RNA-based regulatory mechanisms[4]. HMGB1P5 itself is not a therapeutic target, receptor, enzyme, or transporter.
- Other names
- HMGB1P5high mobility group nucleosome binding domain 1 pseudogene 5
02
Biological functions
Competes for microRNA binding (ceRNA activity)[4]Regulatory function at the RNA level (putative)
03
Disease associations
Cancer (via ceRNA network, not as a direct target)[4]Neurodegenerative diseases (linked by regulatory network, not direct action)[4]Possibly other diseases modulated by parent gene HMGB1 via ceRNA effect
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