High-mobility group box 2 pseudogene (HMGB1P43)

High-mobility group box 2 pseudogene (HMGB1P43, ENSG00000271044) is a genomic DNA sequence classified as a pseudogene due to its homology to the protein-coding HMGB2 gene. Unlike the functional HMGB2 gene, which encodes a non-histone chromatin-binding protein involved in DNA bending, repair, and regulation of gene expression, HMGB1P43 does not produce a functional protein or play a known direct role in biological processes. Pseudogenes such as HMGB1P43 typically lack regulatory elements and accumulate disabling mutations, rendering them nonfunctional. While some pseudogenes have been implicated in regulatory RNA networks or as sources of novel genetic material, there is no indication that HMGB1P43 has such functions[3][5][7]. The "high-mobility group box 2 pseudogene" (ENSG00000271044, HMGB1P43) is a nonfunctional pseudogene and not a valid therapeutic target. It does not encode a protein, does not have known biological functions or disease roles, is not acted on by drugs, and does not serve as a biomarker. The listing as a target is incorrect with respect to therapeutic relevance[3][5][7].

Other names

high-mobility group box 2 pseudogeneHMGB1P43ENSG00000271044

None applicable. Drugs do not target pseudogenes for therapeutic effect