Target intelligence / Profile preview

High mobility group box 3 pseudogene 11 (HMGB3P11)

Target
HMGB3P11
Molecular classification
Other, Pseudogene
01

Overview

High mobility group box 3 pseudogene 11 (HMGB3P11) is a nonfunctional, non-coding DNA segment that resembles the gene for high mobility group box 3 (HMGB3), but contains mutations or alterations that prevent its transcription into a functional protein[1][3]. Pseudogenes such as HMGB3P11 do not produce proteins; their sequences are derived from ancestral functional genes. While most pseudogenes have no function, some have been shown to exert regulatory roles in gene expression (e.g., via RNA interference or acting as microRNA decoys), which may indirectly impact biological pathways or disease, but there is no evidence HMGB3P11 is involved in such processes[2][3].

Other names
HMGB3P11HGNC: 39303NCBI Gene: 644442
02

Mechanism of action

None (not a druggable or functional biomolecule)

03

Biological functions

None as a protein or receptorMay have regulatory RNA function typical of certain pseudogenes (e.g., via RNA interference or acting as microRNA decoys), but no evidence for HMGB3P11
04

Disease associations

None established directly for HMGB3P11Generally, pseudogenes can sometimes regulate related genes in disease contexts

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