High mobility group box 3 pseudogene 18 (HMGB3P18)

High mobility group box 3 pseudogene 18 (HMGB3P18) is classified as a pseudogene, meaning it is a segment of DNA that resembles a functional gene but contains disabling mutations and generally does not encode a functional protein[1]. While some pseudogenes are transcribed and can participate in gene regulation—such as acting as sources of non-coding RNAs or as decoys for microRNAs—the specific biological role and molecular function of HMGB3P18 itself have not been characterized or associated with therapeutic targeting or drug interactions[2][3]. Pseudogenes, including members of the HMGB family, have been implicated in modulating expression of their parent genes through RNA-mediated mechanisms in some cases, but there is no evidence that HMGB3P18 has established functional relevance, biomarker utility, or disease association[2]. It is not considered a therapeutic target or druggable entity, and is likely included in databases as a genomic annotation rather than as a functionally important gene[1][2]. Rationale and clarifications: - The molecule is a pseudogene, **not** a receptor, enzyme, or other therapeutic target[1]. - There is **no evidence** of therapeutic targeting, function, or biomarker utility for HMGB3P18. - The entry is considered **"incorrect"** for a therapeutic target database, as it is a noncoding pseudogene with no established biology in disease or therapy. - Pseudogenes can play regulatory roles in some cases, but this is not established for HMGB3P18 specifically[2][3].

Other names

High mobility group box 3 pseudogene 18HMGB3P18