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Target intelligence / Profile preview
High mobility group box protein 1 (HMGB1)
- Target
- HMGB1
- Molecular classification
- High Mobility Group (HMG) protein, HMGB subfamily, Damage-associated molecular pattern molecule (DAMP)
01
Overview
High mobility group box protein 1 (HMGB1) is a highly conserved, non-histone chromatin-associated protein with diverse roles in cellular biology and disease. It acts as an architectural chromatin-binding factor, facilitates transcription, and interacts with nucleosomes. Extracellularly, it functions as a damage-associated molecular pattern molecule (DAMP), binding to TLRs and RAGE to trigger pro-inflammatory signaling. HMGB1's compartment-specific functions make it central to both normal cellular processes like gene expression regulation and pathological processes involving inflammation or cancer progression.
- Other names
- HMG-1Amphoterin
02
Mechanism of action
Modulation of cytokine/chemotactic activities via redox state of cysteine residues; TLR/RAGE activation
03
Biological functions
Chromatin organizationGene regulationDNA bendingInflammationAutophagyImmune responseTranscriptional regulationDAMP activity
04
Disease associations
SepsisIschemia-reperfusion injuryArthritisCancerHematopoietic malignanciesLeukemiaMultiple myelomaInflammatory disorders
05
Safety considerations
Dysregulation or abnormal release/expression is implicated in numerous diseasesPotential for pro-inflammatory signaling
06
Biomarkers
Extracellular HMGB1 as a biomarker for disease states
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