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Target intelligence / Profile preview
High mobility group nucleosomal binding domain 2 pseudogene 8 (HMGN2P8)
- Target
- HMGN2P8
- Molecular classification
- Other (Pseudogene)
01
Overview
High mobility group nucleosomal binding domain 2 pseudogene 8 (HMGN2P8) is a processed human pseudogene located on chromosome 16. As a pseudogene, it originated from a retrotransposition event, resulting in a nonfunctional, intronless paralog of the HMGN2 gene[6][4]. It does not encode a functional protein and is not known to have a direct biological or therapeutic role. While some pseudogenes can regulate other genes via noncoding RNAs, there is currently no direct evidence that HMGN2P8 has such regulatory function or relevance as a biomarker, drug target, or risk gene[2][3][6]. Its known aliases include AC022394.1 and HMGN2L8[1][3].
- Other names
- AC022394.1HMGN2L8HMGN2P8[1][3]
02
Biological functions
Possible involvement in regulation of gene expression through noncoding RNA mechanisms typical for pseudogenes, such as acting as microRNA decoys or sources of siRNAs, but not direct protein function[2]
03
Disease associations
Other (no direct evidence for disease involvement specific to HMGN2P8; pseudogenes are sometimes implicated in cancer or gene regulation, but no direct link for this locus)[2][3]
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