Target intelligence / Profile preview

High mobility group nucleosome binding domain 1 pseudogene 13 (HMGN1P13)

Target
HMGN1P13
Molecular classification
Pseudogene, Noncoding RNA
01

Overview

High mobility group nucleosome binding domain 1 pseudogene 13 (HMGN1P13) is a human pseudogene with sequence similarity to the HMGN1 gene, which encodes a chromatin-associated protein. Pseudogenes like HMGN1P13 are typically nonfunctional DNA sequences that do not encode active proteins, often arising from gene duplication or retrotransposition events[2][4]. Although classically considered "junk DNA," emerging evidence indicates that some pseudogenes can regulate related protein-coding genes, mainly via noncoding RNA mechanisms such as acting as competing endogenous RNAs or influencing mRNA stability[1][2]. However, there is no established protein function, therapeutic relevance, or disease association specifically for HMGN1P13[4]. The gene is referenced under NCBI Gene ID: 100874439. If the intent was to identify a receptor or protein-coding therapeutic target, then HMGN1P13 is not appropriate: it is a noncoding pseudogene. For the functional protein, refer to the High mobility group nucleosome binding domain 1 (HMGN1) gene, not its pseudogene variant.

Other names
HMGN1P13High mobility group nucleosome binding domain 1 pseudogene 13
02

Mechanism of action

None known; not targeted by therapeutic drugs.

03

Biological functions

May participate in noncoding RNA regulation or microRNA decoy activity, as some pseudogenes doNo direct functional activity as a protein or receptor
04

Disease associations

Pseudogenes can have regulatory or disease relevance, e.g. competing for regulatory RNANo direct evidence for HMGN1P13 in diseaseRoles may include indirect regulation in cancer or other diseases if expressed

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