High mobility group nucleosome binding domain 1 pseudogene 24 (HMGN1P24)

High mobility group nucleosome binding domain 1 pseudogene 24 (HMGN1P24) is a human pseudogene located on chromosome 13[5][1]. As a pseudogene, HMGN1P24 closely resembles the functional *high mobility group nucleosome binding domain 1* (HMGN1) gene but is not believed to code for a functional protein product[4][5]. Its specific biological or clinical roles are unclear, and there is currently no evidence it serves as a direct therapeutic target, receptor, enzyme, or transporter[1][5]. Pseudogenes are increasingly recognized for their potential regulatory functions, in particular as competitive endogenous RNAs (ceRNAs) that may compete for shared microRNAs and thereby modulate the expression of their parental protein-coding genes[6][2][3]. There is some precedent in the high mobility group gene family (*HMGA1* and its pseudogenes) for such RNA-based gene regulation, with *HMGA1-p* shown to destabilize *HMGA1* mRNA and thus indirectly affect genes such as *INSR* (insulin receptor) in type 2 diabetes[3][6]. However, there is no evidence that HMGN1P24 specifically has been implicated in this mechanism or in human disease[1][5]. HMGN1P24 is not currently associated with drug interaction, mechanism of action, biomarker status, safety concerns, or a validated disease role, in contrast to functional protein targets. Its main classification is as a pseudogene, with possible (but unproven) regulatory RNA function analogous to other pseudogenes[6][2][3][5].

Other names

HMGN1P24