High mobility group nucleosome-binding domain-containing protein 1 (HMGN1)

High mobility group nucleosome-binding domain-containing protein 1 (HMGN1) is a small, non-histone chromosomal protein that binds specifically to nucleosomes and influences chromatin structure. It modulates histone post-translational modifications and plays a key role in regulating gene expression, chromatin accessibility, and cellular differentiation. HMGN1 is ubiquitously expressed, most highly during early development and in stem cell populations, and is downregulated as cells differentiate. Loss of HMGN1 impairs responses to DNA damage and cellular stress, leading to increased tumorigenic potential and sensitivity to ionizing or UV radiation. Although HMGN1 strongly affects cell fate and gene regulation, it is not a classical pharmacological target and no drugs directly interact with it

Other names

Non-histone chromosomal protein HMG-14HMGN1HMG14High mobility group nucleosome-binding domain-containing protein 1FLJ27265FLJ31471MGC104230MGC117425High-mobility group nucleosome binding 1Nonhistone chromosomal protein HMG-14

Null. No direct drugs or small molecules have reported mechanisms of action via targeting HMGN1.