High Molecular Weight von Willebrand Factor Multimer (HMW-VWF Multimer)

High molecular weight von Willebrand factor (VWF) multimers are the largest and most functionally active forms of VWF, a multimeric glycoprotein essential for hemostasis. VWF is synthesized as a large precursor protein that undergoes multimerization, resulting in a range of sizes. The high molecular weight forms are particularly important for mediating platelet adhesion and aggregation at sites of vascular injury. These large structures have an α–β–α sandwich fold within their subdomains, and are cleaved by the metalloprotease ADAMTS13. Deficiency or dysfunction leads to bleeding disorders such as von Willebrand disease (VWD), while excessive accumulation due to impaired cleavage can cause microvascular thrombosis.

Other names

Large von Willebrand Factor MultimersHigh Molecular Weight VWFHMW VWFUltra-large von Willebrand factor multimers

Enhances platelet adhesion and aggregation under high shear stress by binding to platelet glycoprotein Ib/IX/V and subendothelial collagen. Stabilizes Factor VIII.