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Target intelligence / Profile preview
Highly expressed in cancer 1 (HEC1)
- Target
- HEC1
- Molecular classification
- Kinetochore protein, Structural protein
01
Overview
Highly expressed in cancer protein 1 (Hec1), a subunit of the Ndc80 complex, is crucial for kinetochore-microtubule attachment and chromosome segregation during mitosis. Overexpression of Hec1 is frequently observed in various cancers and contributes to chromosomal instability, making it a promising target for anticancer therapy.
- Other names
- NDC80 homolog, kinetochore complex componentNDC80
02
Mechanism of action
Disruption of microtubule-Hec1 interaction, leading to chromosome segregation defects, mitotic arrest, and cell death
03
Biological functions
Chromosome segregationKinetochore-microtubule attachmentCell cycle progressionMitosis
04
Disease associations
CancerChromosomal instability
05
Safety considerations
Potential for off-target effects due to microtubule interactionToxicity related to mitotic disruption
06
Biomarkers
HEC1 expression levels (potential for patient selection)
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