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Hippo Signaling Pathway (SWH pathway)
- Target
- SWH pathway
- Molecular classification
- Signaling pathway
01
Overview
The Hippo signaling pathway is a highly conserved regulatory network that controls organ size in animals by regulating cell proliferation, apoptosis, and differentiation. It plays a central role in restricting tissue growth, maintaining tissue homeostasis, and integrating signals from the cellular environment. Dysregulation or down-regulation of Hippo signaling leads to uncontrolled cell growth/proliferation—contributing to cancer development.
- Other names
- Salvador-Warts-Hippo pathway
02
Biological functions
Organ size controlCell proliferation regulationApoptosis regulationCell fate determinationTissue regenerationTissue homeostasisAngiogenesis regulation
03
Disease associations
Cancer
04
Safety considerations
Dysregulation leads to uncontrolled cell growth and cancer development
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