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Hippo-YAP Pathway (Hippo-YAP)
- Target
- Hippo-YAP
- Molecular classification
- Signaling pathway
01
Overview
The Hippo-YAP pathway is a highly conserved signaling cascade that regulates organ size, cell proliferation, apoptosis, and tissue homeostasis. It involves a core set of kinases (MST1/2, LATS1/2), scaffold proteins (SAV1, MOB1A/B), and the transcriptional coactivators YAP and TAZ, which bind to TEAD transcription factors. When the pathway is active, YAP/TAZ are phosphorylated and sequestered in the cytoplasm or degraded, inhibiting gene transcription. When the pathway is inactive, YAP/TAZ translocate to the nucleus and promote gene expression, leading to cell growth and survival. Dysregulation of the Hippo-YAP pathway is implicated in cancer and other diseases.
- Other names
- Hippo pathwayYAP/TAZ pathway
02
Mechanism of action
Modulating post-translational modifications of pathway components; disrupting feed-forward loops
03
Biological functions
Organ size controlCell proliferationApoptosisTissue homeostasisContact inhibitionStem cell maintenanceEpithelial-mesenchymal transition (EMT)Cell growthCell survivalRegeneration
04
Disease associations
Cancer (Hepatocellular carcinoma)Cardiovascular diseasesDiabetes complications (Retinopathy, Nephropathy)
05
Safety considerations
Direct targeting is challenging due to its negative regulatory nature.Dysregulation can lead to tissue overgrowth or cancer formation.
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